Most people with Smith-Magenis syndrome have a broad, square-shaped face with deep-set eyes, full cheeks, and a prominent lower jaw. The middle of the face and the bridge of the nose often appear flattened. The mouth tends to turn downward with a full, outward-curving upper lip.These facial differences can be subtle in early childhood but they usually become more distinctive in later childhood and adulthood. Dental abnormalities are also common in affected individuals.
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